Maggie (Anne Hathaway) is an alluring free spirit who won't let anyone - or anything - tie her down. But she meets her match in Jamie (Jake Gyllenhaal), whose relentless and nearly infallible charm serve him well with the ladies and in the cutthroat world of pharmaceutical sales. Maggie and Jamie's evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.
For U.S. Marshal Carrie Stetko (Kate Beckinsale), things are about to get even more dangerous. The only law enforcement in this unforgiving territory, she has just been sent to investigate a body on the ice. Antarctica’s first homicide. A shocking discovery in itself, it will plunge her into an even more bizarre mystery and the revelation of secrets long-buried under the endless ice…secrets that someone believes are still worth killing for. As Stetko races to find the killer before he finds her, winter is already closing in.